Social Media Application as a New Paradigm for Business Communication: The Role of COVID-19 Knowledge, Social Distancing, and Preventive Attitudes.

Business firms and the public have encountered massive consequences of the COVID-19 pandemic. This pandemic has become the most significant challenge and influenced all communities. This research study focuses on exploring the relationship between COVID-19 knowledge, social distancing, individuals' attitudes toward social media use, and practices of using social media amid the COVID-19 crisis. This study examines how attitudes toward social media use mediate the linkage between COVID-19 knowledge, social distancing, and practices for social media use. This survey uses a non-probability convenience sampling approach to collect samples and recruit willing respondents with their consent for data collection. This study recorded the feedback from 348 participants who encountered the indirect/direct effects of nationwide lockdowns, restrictions on social gatherings, and COVID-19 infection. The findings validate the proposed hypotheses for their direct effects and indicate significant ß-values, t-statistics, and the p-values at p <0.001. The results validate a relationship between the COVID-19 knowledge of and social distancing practices. Similarly, the results approved a positive link between social distancing and attitudes toward social media use amid COVID-19. The findings validate the relation between social distancing and attitudes toward social media use during COVID-19 challenges (ß-value = 0.22 and t-statistics = 3.078). The results show the linkage between attitudes toward social media use and practices of using social media (ß-value = 0.41, and t-statistics = 7.175). Individuals' attitude toward social media use during COVID-19 mediates the connection between COVID-19 knowledge and COVID-19 practices of using social media use. The results validate the first mediation at ß-value = 0.21 and t-statistic = 5.327. Similarly, the findings approve that attitudes toward social media use in the pandemic have positively mediated the relation between distancing and practices for social media use amid the crisis of COVID-19 (ß-value = 0.09 and t-statistic = 2.633). The findings indicate how people have been indulged in social media to pave their business communication needs. The results provide valuable insights for the global business community. This study provides a systematic and holistic research model that helps in exploring the consequences of COVID-19. The generalizability of the findings provides valuable directions for future research related to the current pandemic.

Community Wellbeing Under China-Pakistan Economic Corridor: Role of Social, Economic, Cultural, and Educational Factors in Improving Residents' Quality of Life.

This present article explores the effects of cultural value, economic prosperity, and community mental wellbeing through multi-sectoral infrastructure growth projects under the Belt and Road Initiative. The implications of the social exchange theory are applied to observe the support of the local community for the China-Pakistan Economic Corridor (CPEC). This study explores the CPEC initiative, it's direct social, cultural, economic development, and risk of environmental factors that affect residents' lives and the local community's wellbeing. CPEC is a multibillion-dollar project to uplift economic growth and free trade between Pakistan, China, and other regional stakeholders. Although CPEC is still in its initial phases with partial startups, policymakers and government officials claim this mega project as a "game-changer" in the region, mainly for Pakistan and China. This gigantic project offers the significant potential to generate business slews and employment opportunities with international outreach. Due to the term's newness, numerous studies have recently explored the macro and microeconomic benefits of the CPEC initiatives; still, these projects are theoretical. The existing literature insufficiently explored how helpful CPEC would be to a specific group and how residents perceive its advantages. This study fills in the literature gaps and explores the likely advantageous potential of the CPEC for the regional states. The study applied a convenient sampling technique for the data collection process. It used a mixed-method approach to gain scientific results, with a standardized questionnaire survey of 459 people (300 men and 159 women) from five major cities of Pakistan. The study results designate that residents believe that CPEC infrastructure projects will significantly improve residents' life quality through more job openings and community poverty reduction. Still, they raised their concerns regarding environmental protection issues in the region. The findings specified that residents had an optimistic approach to better educational productivity by adopting environment-oriented policies. Policymakers should establish new CPEC study centers in different areas, and investors should be encouraged to participate in the industrial sector. Officials can overwhelm community worries about environmental degradation. Government officials in both countries can utilize the findings to raise public awareness about CPEC's social, economic, cultural, mental wellbeing, and ecological implications.

Genome sequencing and analysis of genomic diversity in the locally transmitted SARS-CoV-2 in Pakistan.

Surveillance of genetic diversity of the SARS-CoV-2 is extremely important to detect the emergence of more infectious and deadly strains of the virus. In this study, we evaluated mutational events in the SARS-CoV-2 genomes through whole genome sequencing. The samples were collected from COVID-19 patients in different major cities of Pakistan during the four waves of the pandemic (May 2020 to July 2021) and subjected to whole genome sequencing. Using in silico and machine learning tools, the viral mutational events were analyzed, and variants of concern and of interest were identified during each of the four waves. The overall mutation frequency (mutations per genome) increased during the course of the pandemic from 12.19 to 23.63, 31.03, and 41.22 in the first, second, third, and fourth waves, respectively. We determined that the viral strains rose to higher frequencies in local transmission. The first wave had three most common strains B.1.36, B.1.160, and B.1.255, the second wave comprised B.1.36 and B.1.247 strains, the third wave had B.1.1.7 (Alpha variant) and B.1.36 strains, and the fourth waves comprised B.1.617.2 (Delta). Intriguingly, the B.1.36 variants were found in all the waves of the infection indicating their survival fitness. Through phylogenetic analysis, the probable routes of transmission of various strains in the country were determined. Collectively, our study provided an insight into the evolution of SARS-CoV-2 lineages in the spatiotemporal local transmission during different waves of the pandemic, which aided the state institutions in implementing adequate preventive measures.

Management of appendicitis during COVID-19 pandemic; short-term outcomes.

BACKGROUND AND AIM: COVID-19 pandemic has predisposed patients undergoing surgery to post-operative infection and resultant complications. Appendicitis is frequently managed by appendicectomy. After the onset of the pandemic, selected cases of appendicitis were managed with antibiotics which is a recognised treatment option. Our objective was to compare the management of appendicitis and post-operative outcomes between pre- and post-COVID-19. METHODS: Ninety-six patients were identified from before the onset of the pandemic (November 2019) to after the onset of the pandemic (May 2020). Data were collected retrospectively from electronic records including demographics, investigations, treatment, duration of inpatient stay, complications, readmissions and compared between pre- and post-COVID-19 groups. RESULTS: One hundred percent underwent surgical treatment before the onset of pandemic, compared with 56.3% from the onset of the pandemic. A greater percentage of patients were investigated with imaging post-COVID-19 (100% versus 60.9%; p < 0.00001). There was no significant difference in the outcomes between the two groups. CONCLUSION: CT/MRI scan was preferred to laparoscopy in diagnosing appendicitis and conservative management of uncomplicated appendicitis was common practice after the onset of pandemic. Health boards can adapt their management of surgical conditions during pandemics without adverse short-term consequences. Long term follow-up of this cohort will identify patients suitable for conservative management.